Polymyxin B Sulfate Powder

Polymyxin B Sulfate Powder actively disrupts cell membrane permeability by binding to it. Bacteria lacking sensitivity to Polymyxin B Sulfate possess cell walls that block its access to the cell membrane. This antibiotic lacks efficacy against gram-positive bacteria and Polymyxin B sulfate powder binds to the cell membrane thereby removing its permeability.

Bacteria that are not sensitive to polymyxin B sulfate have a cell wall that prevents polymyxin from reaching the cell membrane. This antibiotic does not affect the gram-positive bacteria, nor does it affect anaerobes. It does affect the gram-negative bacteria including the non-fermentative and Enterobacteriaceae strains.
The mechanism of action of this antibiotic is that, polymyxin B sulfate binds to the lipopolysaccharides in the outer membrane of gram-negative bacteria. This binding destroys the cell membrane integrity leads to leakage of intracellular content out and death of bacteria.
In clinical practice, polymyxin B sulfate is usually used as the last resort against multidrug-resistant infections. This antibiotic has activity against nosocomial infections caused by Pseudomonas aeruginosa and Acinetobacter baumannii.
In summary, polymyxin B sulfate powder is capable of actively destroying the integrity of the cell wall and effective against multidrug-resistant gram-negative bacteria. Its essential role as a last-line treatment also shows its importance in the clinical applications, especially with infections for which other antibiotics are not effective.